One-pot synthesis of optically active cyanohydrin acetates from aldehydes via lipase-catalyzed kinetic resolution coupled with in situ formation and racemization of …

M Inagaki, J Hiratake, T Nishioka…

Index: Inagaki, Minoru; Hiratake, Jun; Nishioka, Takaaki; Oda, Jun'ichi Journal of Organic Chemistry, 1992 , vol. 57, # 21 p. 5643 - 5649

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Citation Number: 136

Abstract

A novel one-pot synthesis of optically active cyanohydrin acetates from aldehydes has been accomplished by lipase-catalyzed kinetic resolution coupled with in situ formation and racemization of cyanohydrins in an organic solvent. Racemic cyanohydrins 2, generated from aldehydes 1 and acetone cyanohydrin in diisopropyl ether under the catalysis of basic anion-exchange resin (OH-form), were acetylated stereoselectively by a lipase from ...