An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives.: Structure–activity comparative studies with isomeric pyrroloquinolines

…, A Tsotinis, LR Kelland, DE Thurston

Index: Vlachou, Margarita; Tsotinis, Andrew; Kelland, Lloyd R.; Thurston, David E. Heterocycles, 2002 , vol. 57, # 1 p. 129 - 133

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Citation Number: 8

Abstract

A number of pyrroloisoquinolines have been prepared by reaction of 5-nitroisoquinoline with vinylmagnesium bromide followed by N-alkylation with the appropriate 2-chloro-N, N- dialkylethylamine. Their cytotoxicity was evaluated in a number of ovarian cell lines and compared to their analogous isomeric pyrroloquinolines. Two of the new compounds, 7c and 7d, are selective toward the A2780 cisplatin-resistant line.