Tetrahedron Letters

Scope and limitations of the Minisci reaction for the synthesis of aza-heterocycles

RN Burgin, S Jones, B Tarbit

Index: Burgin, Ryan N.; Jones, Simon; Tarbit Tetrahedron Letters, 2009 , vol. 50, # 49 p. 6772 - 6774

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Citation Number: 6

Abstract

Attempts to prepare several classes of aza-heterocycles by application of the Minisci radical cyclisation reaction are described. Competing β-scission, hydrolytic cleavage and lactonisation reactions were found to be major hurdles to adopting this strategy for the synthesis of such targets.

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