Scope and Limitations of Auxiliary-Assisted, Palladium-Catalyzed Arylation and Alkylation of sp2 and sp3 C–H Bonds

…, GIF Santos, D Shabashov, O Daugulis

Index: Truong, Thanh; Klimovica, Kristine; Daugulis, Olafs Journal of the American Chemical Society, 2013 , vol. 135, # 25 p. 9342 - 9345

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Citation Number: 100

Abstract

The scope of palladium-catalyzed, auxiliary-assisted direct arylation and alkylation of sp2 and sp3 C–H bonds of amine and carboxylic acid derivatives has been investigated. The method employs a palladium acetate catalyst, substrate, aryl, alkyl, benzyl, or allyl halide, and inorganic base in tert-amyl alcohol or water solvent at 100–140° C. Aryl and alkyl iodides as well as benzyl and allyl bromides are competent reagents in this transformation ...