Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent 1

A Gangjee, J Yu, JJ McGuire, V Cody…

Index: Tomazic; Hynes Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 915 - 920

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Citation Number: 73

Abstract

... Journal of Medicinal ... J. Med. Chem. ... 2,4-Diaminoquinazoline analogues as dual inhibitors were reported by Hynes et al. 21 with the suggestion that chemotherapeutic utility of such analogues would require that the inhibitory activity against DHFR be similar to that against TS. ...