Development of synthetic compounds with glutathione peroxidase activity

…, PA Zucker, RRC Huang, A Spector

Index: Wilson, Stephen R.; Zucker, Paul A.; Huang, Ruey-Ruey C.; Spector, Abraham Journal of the American Chemical Society, 1989 , vol. 111, # 15 p. 5936 - 5939

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Citation Number: 371

Abstract

Abstract: Glutathione peroxidase is the major defense in the lens of the eye against hydrogen peroxide. The damage caused by hydrogen peroxide has been implicated in the formation of cataract. Organoselenium compounds which show catalytic activity in the enzyme assay for the selenoenzyme glutathione peroxidase have been prepared. These compounds were designed on the basis of the known chemistry of models for the active ...