Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes

GR Morais, HV Miranda, IC Santos, I Santos…

Index: Ribeiro Morais, Goreti; Vicente Miranda, Hugo; Santos, Isabel C.; Santos, Isabel; Outeiro, Tiago F.; Paulo, Antonio Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 24 p. 7698 - 7710

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Citation Number: 14

Abstract

The formation of proteinaceous aggregates is a pathognomonic hallmark of several neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. To date, the final diagnostic for these diseases can only be achieved by immunostaining of post-mortem brain tissues with the commonly used congo red and Thioflavin T/S amyloid-dyes. The interest in developing amyloid-avid radioprobes to be used for protein aggregates ...