2-Methylwyosine, a Nucleoside With Restricted Anti Conformation in the East Region Enforced by Nucleobase Moiety Modification: Synthesis and Conformational …

D Baranowski, B Golankiewicz, W Folkman…

Index: Baranowski, Daniel; Golankiewicz, Bozenna; Folkman, Wojciech; Popenda, Mariusz Nucleosides, Nucleotides and Nucleic Acids, 2012 , vol. 31, # 10 p. 707 - 719

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Abstract

GRAPHICAL ABSTRACT We synthesized a new 2-methyl derivative of wyosine using a multistep procedure starting from guanosine. We examined different synthetic paths and optimized the conditions for each step. Based on MD calculations and analysis of the 3 J HH and J C1′ H1′ of the ribose moiety, we discovered that the sugar part adopted conformation specific for the East region rarely occurring in solution. This unusual ...