An Organocatalytic Cascade Approach toward Polysubstituted Quinolines and Chiral 1, 4??Dihydroquinolines–Unanticipated Effect of N??Protecting Groups

X Zhang, X Song, H Li, S Zhang, X Chen…

Index: Zhang, Xinshuai; Song, Xixi; Li, Hao; Zhang, Shilei; Chen, Xiaobei; Yu, Xinhong; Wang, Wei Angewandte Chemie - International Edition, 2012 , vol. 51, # 29 p. 7282 - 7286

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Citation Number: 48

Abstract

Organocatalytic cascade reactions have been established as a viable and efficient approach to complex molecular architectures,[1] however, examples of the combination of powerful divergent synthesis with an organocatalytic cascade strategy are rare.[2] Herein, we report a powerful divergent organocatalytic cascade reaction that proceeds via a chiral allenamine [3] and involves unprecedented aza-Michael/aldol and aza-Michael/aldol/aromatization ...