Synthesis and evaluation of analogues of Congo red as potential compounds against transmissible spongiform encephalopathies

H Rudyk, MH Knaggs, S Vasiljevic, J Hope…

Index: Rudyk, Helene; Knaggs, Michael H.; Vasiljevic, Snezana; Hope, James; Birkett, Chris; Gilbert, Ian H. European Journal of Medicinal Chemistry, 2003 , vol. 38, # 6 p. 567 - 579

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Citation Number: 50

Abstract

The synthesis of analogues of the amyloid stain Congo red (1) as potential compounds against transmissible spongiform encephalopathies (TSEs) is reported. Using the direct method, aniline (2) or diamines such as 4, 4′-diaminodiphenylsulfone (dapsone, 9), 3, 3′- diaminodiphenylsulfone (10), benzidine (11), 3, 3′-dimethoxybenzidine (12) or 3, 3′- dichlorobenzidine (13) were diazotised to afford the corresponding diazonium salts, which ...