A detective story in drug discovery: elucidation of a screening artifact reveals polymeric carboxylic acids as potent inhibitors of RNA polymerase

W Zhu, M Groh, J Haupenthal…

Index: Zhu, Weixing; Groh, Matthias; Haupenthal, Joerg; Hartmann, Rolf W. Chemistry - A European Journal, 2013 , vol. 19, # 26 p. 8397 - 8400

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Citation Number: 12

Abstract

Scientific progress is hampered by publications with erroneous results.[1] An improvement of this nuisance will depend on an enhanced alertness of researchers and reviewers of experimental artifacts. In the field of drug discovery high-throughput screening traditionally performed by the pharmaceutical industry, has found its way into academic research.[2] The hit compounds are reported to the scientific community as good starting points for drug ...