Total synthesis of gelsemoxonine
J Shimokawa, T Harada, S Yokoshima…
Index: Shimokawa, Jun; Harada, Takaaki; Yokoshima, Satoshi; Fukuyama, Tohru Journal of the American Chemical Society, 2011 , vol. 133, # 44 p. 17634 - 17637
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Citation Number: 53
Abstract
The first total synthesis of gelsemoxonine (1) has been accomplished. Divinylcyclopropane– cycloheptadiene rearrangement of the highly functionalized substrate was successfully applied to assemble the spiro-quaternary carbon center connected to the bicyclic seven- membered core structure. A one-pot isomerization reaction of the α, β-unsaturated aldehyde to the saturated ester via the TMSCN–DBU reagent combination allowed a facile ...
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