CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example

…, F Calderón, T Doménech, A Nueda, A Martínez

Index: Castro, Ana; Jerez, Maria Jose; Gil, Carmen; Calderon, Felix; Domenech, Teresa; Nueda, Arsenio; Martinez, Ana European Journal of Medicinal Chemistry, 2008 , vol. 43, # 7 p. 1349 - 1359

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Citation Number: 32

Abstract

Phosphodiesterase (PDE) 7 is a high affinity cAMP-specific PDE whose functional role in T- cells has been the subject of some controversy. Recent findings on tissue distribution, however, support the hypothesis that PDE7 could be a good target for the treatment of airway diseases, T-cell related diseases or central nervous system (CNS) disorders. Therefore, the identification of selective inhibitors targeted against PDE7 enzyme has ...