Tetrahedron

Highly selective trifluoroacetic ester/ketone metathesis: an efficient approach to trifluoromethyl ketones and esters

Y Zhou, D Yang, G Luo, Y Zhao, Y Luo, N Xue, J Qu

Index: Zhou, Yuhan; Yang, Dongmei; Luo, Gen; Zhao, Yilong; Luo, Yi; Xue, Na; Qu, Jingping Tetrahedron, 2014 , vol. 70, # 31 p. 4668 - 4674

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Citation Number: 5

Abstract

Abstract A highly selective and atom efficient 'trifluoroacetic ester/ketone metathesis' has been sincerely witnessed. Enolizable alkyl (at least two non-hydrogen atoms) aryl ketones were found to react readily with ethyl trifluoroacetate under the promotion of NaH to afford trifluoroacetic ester/ketone exchange products, trifluoromethyl ketones (TFMKs), and aromatic acid esters, which were quite different from the general Claisen condensation ...