1-Benzopyran-4-one antioxidants as aldose reductase inhibitors

L Costantino, G Rastelli, MC Gamberini…

Index: Costantino, Luca; Rastelli, Giulio; Gamberini, Maria Cristina; Vinson, Joe A.; Bose, Pratima; Iannone, Anna; Staffieri, Mariagrazia; Antolini, Luciano; Del Corso, Antonella; Mura, Umberto; Albasini, Albano Journal of Medicinal Chemistry, 1999 , vol. 42, # 11 p. 1881 - 1893

Full Text: HTML

Citation Number: 106

Abstract

Starting from the inhibitory activity of the flavonoid Quercetin, a series of 4 H-1-benzopyran-4- one derivatives was synthesized and tested for inhibition of aldose reductase, an enzyme involved in the appearance of diabetic complications. Some of the compounds obtained display inhibitory activity similar to that of Sorbinil but are more selective than Quercetin and Sorbinil with respect to the closely related enzyme, aldehyde reductase, and also possess ...