Analogs of substance P. Peptides containing D-amino acid residues in various positions of substance P and displaying agonist or receptor selective antagonist effects

AS Dutta, JJ Gormley, AS Graham, I Briggs…

Index: Dutta; Gormley; Graham; Briggs; Growcott; Jamieson Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1163 - 1171

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Citation Number: 19

Abstract

Agonist and antagonist analogues of substance P were synthesized by replacing at least two of the amino acid residues with D-Trp, D-Phe,~-Val, or D-Pro residues. The syntheses of these compounds were achieved by solid-phase methodology using the hydroxymethyl resin. The analogues were tested for agonist and antagonist activity on guinea pig ileum and rat spinal cord preparations. Two types of antagonists were obtained. The first type of ...