Cyclic RGD peptide analogs as antiplatelet antithrombotics

…, S Bullens, S Bunting, DJ Burdick…

Index: Barker, Peter L.; Bullens, Sherron; Bunting, Stuart; Burdick, Daniel J.; Chan, Kathryn S.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 11 p. 2040 - 2048

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Citation Number: 185

Abstract

Stimulation of platelets activates GPIIbIIIa, the heterodimeric integrin receptor, to bind fibrinogen (Fg), which results in platelet aggregation. GPIIbIIIa/Fg binding inhibitors are potentially suitable for acute use during and after thrombolytic therapy as antithrombotic agents. Incorporation of the tripeptide sequence Arg-Gly-Asp (RGD), a common structural element of many integrin ligands, into cyclic peptides produced a series of peptides of the ...