The asymmetric Friedel–Crafts reaction of indoles with fluoroalkylated nitroalkenes catalyzed by chiral phosphoric acid
JH Lin, JC Xiao
Index: Lin, Jin-Hong; Xiao, Ji-Chang European Journal of Organic Chemistry, 2011 , # 24 p. 4536 - 4539
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Citation Number: 24
Abstract
Abstract The enantioselective Friedel–Crafts fluoroalkylation of indoles with fluoroalkylated nitroalkenes, catalyzed by chiral phosphoric acid is described. The regioselectivity of fluoroalkylated nitroalkenes is a problem worth discussing, and it was found that the carbon atom adjacent to the fluoroalkyl group is more reactive than that adjacent to NO 2 group.
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