Fluorogenic aldehydes bearing arylethynyl groups: turn-on aldol reaction sensors for evaluation of organocatalysis in DMSO

…, A Sugita, T Narumi, M Toda, N Watanabe, F Tanaka

Index: Mase, Nobuyuki; Ando, Taishi; Shibagaki, Fumiya; Sugita, Atsushi; Narumi, Tetsuo; Toda, Mitsuo; Watanabe, Naoharu; Tanaka, Fujie Tetrahedron Letters, 2014 , vol. 55, # 11 p. 1946 - 1948

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Abstract

Abstract Fluorogenic aromatic aldehydes bearing arylethynyl groups were developed. They were used for monitoring the reaction progress of organocatalytic aldol reactions in DMSO through an increase in the fluorescence intensity based on the formation of the florescent aldol product. The ratios of the fluorescence intensities of the aldols to the aldehydes were more than 300. These results suggest that the fluorescence assay system using the ...