Tetrahedron letters

Synthesis of homochiral L-(S)-tert-leucine via a lipase catalysed dynamic resolution process

NJ Turner, JR Winterman, R McCague, JS Parratt…

Index: Turner, Nicholas J.; Winterman, James R.; McCague, Raymond; Parratt, Julian S.; Taylor, Stephen J. C. Tetrahedron Letters, 1995 , vol. 36, # 7 p. 1113 - 1116

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Citation Number: 100

Abstract

Treatment of (±)-2-phenyl-4-tert-butyloxazolin-5 (4H)-one 8 with Lipozyme®(Mucor miehei) in toluene containing n-butanol and a catalytic amount of triethylamine resulted in a 94% yield of (S)-N-benzoyltert-leucine butyl ester 9 (99.5% ee). Subsequent two step hydrolysis (Alcalase® followed by 6N HCl, reflux) yielded homochiral l-(S)-tert-leucine 1.

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