Synthesis

Efficient synthesis of monosubstituted 3-alkynylfurans via Suzuki coupling

X Yang, L Zhu, Y Zhou, Z Li, H Zhai

Index: Yang, Xiaobao; Zhu, Li; Zhou, Yuedong; Li, Zhong; Zhai, Hongbin Synthesis, 2008 , # 11 p. 1729 - 1732

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Citation Number: 8

Abstract

Abstract A convenient synthesis of monosubstituted 3-alkynylfurans by Suzuki coupling reaction of 3-furanylboronic acid with substituted acetylene bromides is described. The internal alkyne products were attainable in 50-89% yields from substrates free of relatively acidic protons. Our protocol is expected to find applications in the synthesis of structurally related natural products.