Maleamic acids that affect plasma cholesterol and penicillin excretion

EM Schultz, WA Bolhofer, A Augenblick…

Index: Schultz,E.M. et al. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 717 - 724

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Citation Number: 8

Abstract

A number of maleamic acids have been prepared by the reaction of maleic anhydride with an appropriate amine. In general, the amines are of the di-and triphenyl-substituted alkyl type for which synthetic procedures are given. Some of these have two asymmetric centers and in most instances both of the racemates were obtained in pure form. Compounds were prepared to show the biological effect of (a) the degree of substitution on the amide ...