Molecules

Synthesis of the Aspidosperma Alkaloid Na-Formyl-16-α-Hydroxyaspidospermidine

F Belferdi, A Belattar

Index: Belferdi, Fatiha; Belattar, Abdelhamid Molecules, 2001 , vol. 6, # 10 p. 803 - 814

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Abstract

The existing literature method for the conversion of the readily available (±)-vincadifformine (2) into the key intermediate 16-hydroxyindolenine (3) showed that the latter compound is particularly unstable [7, 8]. Similarly, photo-oxygenation [9] of 2 in the presence of Rose Bengal and sodium thiosulphate as reducing agent to give 16-hydroxyindolenine (3) resulted in low yields of the desired compound. The other product was mainly recovered starting material. This is ...