Benzylation via Tandem Grignard reaction—iodotrimethylsilane (TMSI) mediated reduction

EJ Stoner, DA Cothron, MK Balmer, BA Roden

Index: Stoner, Eric J.; Cothron, Darlene A.; Balmer, Mary K.; Roden, Brian A. Tetrahedron, 1995 , vol. 51, # 41 p. 11043 - 11062

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Citation Number: 48

Abstract

A method has been developed which allows for the large scale preparation of biarylmethanes This method involves the initial formation of biarylmethanols via reaction of aryl Grignards with carbonyl compounds followed by a subsequent reduction with iodotrimethylsilane (TMSI). A number of improvements over existing literature procedures are reported as well as previously unobserved dimenzations. Studies reveal that as few as ...