Journal of medicinal chemistry

Synthesis and antiinflammatory activity of cis-4, 5, 6, 7, 8, 8a, 9-hexahydro-. alpha.-methyl-5H-fluorene-2-acetic acid

PW Sprague, JE Heikes

Index: Sprague,P.W.; Heikes,J.E. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 726 - 728

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Citation Number: 4

Abstract

of p-fluorobenzamidrazone (2 g, 0.013 mol) was added to a hot aqueous solution of glyoxal bisulfite (10 g, 0.043 mol). After 5 min of heating, the reaction mixture was filtered, and the mother liquor was basified and extracted with ether. Removal of the solvent gave a residue which was crystallized from 2-propanol to give 1.1 g (50%) of product: mp 102-106 OC;'H NMR (CDC13) 6 9.19 (d, 1, J= 3 Hz), 8.64 (d, 1, J= 3 Hz), 8.54 (m, 2, mom H), 7.20 (m, 2, ...