N-Cycloalkanoyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists

…, G Kaplan, A Sheffron, L Chen, R Campbell…

Index: Sidduri, Achyutharao; Tilley, Jefferson W; Hull, Kenneth; Lou, Jian Ping; Kaplan, Gerry; Sheffron, Allen; Chen; Campbell, Robert; Guthrie, Robert; Huang, Tai-Nan; Huby, Nicholas; Rowan, Karen; Schwinge, Virginia; Renzetti, Louis M Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 17 p. 2475 - 2478

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Citation Number: 11

Abstract

A systematic structure–activity relationship investigation of the lead compound 1 resulted the identification of several N-[(substituted alkyl) cycloalkanoyl]-4-[((2, 6-dichlorophenyl) carbonyl) amino]-l-phenylalanine derivatives as potent VCAM/VLA-4 antagonists. The ...