Copper??Catalyzed Trifluoromethylation of Aryl Iodides with Potassium (Trifluoromethyl) trimethoxyborate

T Knauber, F Arikan, GV Röschenthaler…

Index: Knauber, Thomas; Arikan, Fatih; Roeschenthaler, Gerd-Volker; Goossen, Lukas J. Chemistry - A European Journal, 2011 , vol. 17, # 9 p. 2689 - 2697

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Citation Number: 171

Abstract

Abstract Potassium (trifluoromethyl) trimethoxyborate is introduced as a new source of CF 3 nucleophiles in copper-catalyzed trifluoromethylation reactions. The crystalline salt is stable on storage, easy to handle, and can be obtained in near-quantitative yields simply by mixing B (OMe) 3, CF 3 SiMe 3, and KF. The trifluoromethylation reagent allows the conversion of various aryl iodides into the corresponding benzotrifluorides in high yields under mild, ...