Liebigs Annalen der Chemie

A new route to 2′, 3′??dideoxycytidine

MS Motawia, EB Pedersen

Index: Motawia, Mohammed S.; Pedersen, Erik B. Liebigs Annalen der Chemie, 1990 ,  # 6  p. 599 - 602

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Citation Number: 33

Abstract

Abstract 2-Deoxy-D-ribose (1) was converted into its methyl glycofuranoside 2, which was treated with 4-biphenylcarbonyl chloride to give a separable mixture of 3 (26%) and 4 (40%). Compounds 3 and 4 were deoxygenated by Barton deoxygenation to give the corresponding 2, 3-dideoxyribose derivatives 7 and 8 in good yields as crystalline materials. Reaction of 7 and 8 with the silylated N 4-isobutyrylcytosine 9, using trimethylsilyl triflate ...