Synthesis and antiviral and cytostatic properties of 3'-deoxy-3'-fluoro-and 2'-azido-3'-fluoro-2', 3'-dideoxy-D-ribofuranosides of natural heterocyclic bases

…, EI Kvasyuk, J Balzarini, E De Clercq

Index: Mikhailopulo; Poopeiko; Pricota; Sivets; Kvasyuk; Balzarini; De Clercq Journal of Medicinal Chemistry, 1991 ,  vol. 34,  # 7  p. 2195 - 2202

Full Text: HTML

Citation Number: 61

Abstract

The analogues of natural 2'-deoxyribonucleosides in which the hydroxy group at C3'is substituted by a fluorine atom in the rib0 configuration exhibit a wide range of biological properties'+ following their intracellular conversion to 5'-tripho~ phates.'*'~ The latter act as competitive inhibitors1* 13 and/or alternate sub~ trates'~ J~~~ of some DNA polymerases, depending on the experimental conditions~ sed.~'J~ J~ When being substrates, the ...