The total synthesis of the polyether antibiotic X-206

DA Evans, SL Bender, J Morris

Index: Evans; Bender; Morris Journal of the American Chemical Society, 1988 ,  vol. 110,  # 8  p. 2506 - 2526

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Citation Number: 246

Abstract

Abstract: A convergent asymmetric synthesis of the polyether antibiotic X-206 has been achieved through the synthesis and coupling of the CI-C16 and C17-C37 synthons 16 and 17, respectively. All absolute stereochemical relationships within the molecule were controlled by application of recent methodological advances in asymmetric synthesis. In the synthesis of subunit 16, both the alkylation and aldol reactions of chiral imide-derived ...