Tetrahedron

An efficient synthesis of ([18 F] fluoropropyl) quinoline-5, 8-diones by rapid radiofluorination–oxidative demethylation

K Sachin, HJ Jeong, ST Lim, MH Sohn, DY Chi…

Index: Sachin, Kalme; Jeong, Hwan-Jeong; Lim, Seok Tae; Sohn, Myung-Hee; Chi, Dae Yoon; Kim, Dong Wook Tetrahedron, 2011 ,  vol. 67,  # 10  p. 1763 - 1767

Full Text: HTML

Citation Number: 8

Abstract

Since many molecules bearing quinoline-5, 8-dione or fused 1, 4-quinone moieties possess a wide spectrum of biological activities, efficient methods for incorporation of fluorine-18 (F- 18) into quinoline-5, 8-diones have received considerable attention in positron emission tomography (PET) molecular imaging studies. In this paper, we describe an efficient synthetic route for the regioselective preparation of fluoropropyl-substituted quinoline-5, 8- ...