Organic letters

Copper-catalyzed N-alkynylations of sulfoximines with bromoacetylenes

XY Chen, L Wang, M Frings, C Bolm

Index: Chen, Xiao Yun; Wang, Long; Frings, Marcus; Bolm, Carsten Organic Letters, 2014 ,  vol. 16,  # 14  p. 3796 - 3799

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Citation Number: 25

Abstract

For the initial phase of the project, S-methyl-S-phenylsulfoximine (1a) and 1-bromo-2-phenylacetylene (5a) were chosen as substrates, which we expected to provide N-alkynylated sulfoximine 3a after the coupling. Because of the particular properties of the sulfoximines, an extensive screening of reaction conditions was necessary to get the first positive results. Ultimately, a slightly modified procedure of Hsung's original protocol(13d) as described by Yorimitsu, Oshima, and co- ...