Tetrahedron: Asymmetry

Selective incorporation of CF 2-group into the natural compounds molecules. Synthesis of 14, 14-difluorocoriolic acid

AM Kornilov, IB Kulik, AE Sorochinsky…

Index: Kornilov; Kulik; Sorochinsky; Kukhar Tetrahedron Asymmetry, 1995 ,  vol. 6,  # 1  p. 199 - 206

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Citation Number: 7

Abstract

The difluorides obtained in the reaction of DAST with appropriate ketones could serve as a suitable starting materials for the selective incorporation of CF2-group into the molecules of the unsaturated chiral natural compounds. As an example, stereoselective synthesis of (R)- 14, 14-difluoro-13-hydroxy-9 (Z), 11 (E)-octadecadienoic acid [(R)-14, 14-difluorocoriolic acid] 6 is reported.