Tetrahedron letters

A new pyridine synthesis starting from α, β-unsaturated carbonyl compounds

K Konno, K Hashimoto, H Shirahama, T Matsumoto

Index: Konno, Katsuhiro; Hashimoto, Kimiko; Shirahama, Haruhisa; Matsumoto, Takeshi Tetrahedron Letters, 1986 ,  vol. 27,  # 33  p. 3865 - 3868

Full Text: HTML

Citation Number: 16

Abstract

Abstract A new and mild synthetic method of substituted pyridines from α, β-unsaturated carbonyl compounds through a sequence involing (1) 1, 4-conjugate addition of thiophenol (2) condensation with a methylene ketone (3) Pummerer rearrangement to an unsaturated 1, 5-dicarbonyl compound (4) treatment with ammonia is described.