Tetrahedron: Asymmetry

Asymmetric enzymatic hydrolysis of prochiral 2-O-allylglycerol ester derivatives

B Wirz, R Schmid, J Foricher

Index: Wirz, Beat; Schmid, Rudolf; Foricher, Joseph Tetrahedron: Asymmetry, 1992 ,  vol. 3,  # 1  p. 137 - 142

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Citation Number: 13

Abstract

Abstract The generation of optically active glycerol derivatives via enzymatic ester hydrolysis of prochiral 1, 3-diacyl derivatives of 2-O-allyl protected glycerol has been investigated. Lipase M-AP, under optimum conditions, afforded asymmetric inductions of 94–96% ee. The obtained (R)-monoacyl derivative was converted to (S)-configurated tosylglycerol compounds.