'Naked'and Hydrated Conformers of the Conserved Core Pentasaccharide of N-linked Glycoproteins and Its Building Blocks

…, SM Remmert, MC Fernández-Alonso…

Index: Barry, Conor S.; Cocinero, Emilio J.; Carcabal, Pierre; Gamblin, David P.; Stanca-Kaposta, E. Cristina; Remmert, Sarah M.; Fernandez-Alonso, Maria C.; Rudic, Svemir; Simons, John P.; Davis, Benjamin G. Journal of the American Chemical Society, 2013 ,  vol. 135,  # 45  p. 16895 - 16903

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Citation Number: 10

Abstract

N-glycosylation of eukaryotic proteins is widespread and vital to survival. The pentasaccharide unit− Man3GlcNAc2–lies at the protein-junction core of all oligosaccharides attached to asparagine side chains during this process. Although its absolute conservation implies an indispensable role, associated perhaps with its structure, its unbiased conformation and the potential modulating role of solvation are unknown; ...