Tetrahedron: Asymmetry

Synthesis, resolution and application of 2, 2′-bis (di-2-furylphosphino)-1, 1′-binaphthalene

NG Andersen, R McDonald, BA Keay

Index: Andersen, Neil G.; McDonald, Robert; Keay, Brian A. Tetrahedron Asymmetry, 2001 , vol. 12, # 2 p. 263 - 269

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Citation Number: 49

Abstract

Homochiral bidentate phosphine ligands play a vital role in homogeneous transition metal catalyzed asymmetric synthesis. 1 Since the initial reports with BINAP 1 (Scheme 1), 2., , and a wide variety of new biaryl, bidentate ligands have appeared in the literature. 3 However, evidence has been reported to suggest that less electron rich phosphines, like tri-2-furylphosphine 2 (TFP, Scheme 1), are advantageous for some transition metal mediated organic reactions. 4., and These ...