Tetrahedron letters

Directed regioselectivity of bromination of ketones with NBS: solvent-free conditions versus water

I Pravst, M Zupan, S Stavber

Index: Pravst, Igor; Zupan, Marko; Stavber, Stojan Tetrahedron Letters, 2006 , vol. 47, # 27 p. 4707 - 4710

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Citation Number: 61

Abstract

Demands for sustainable and ecologically friendly organic syntheses have led to investigations of the conditions involved in reactions. 1 Among these conditions, solvent-free strategies 2 and the use of water 3 as the reaction medium represent important alternatives. Very recently, Sharpless and co-workers 4 reported an important observation that some organic molecules can react on the surface of water, and in some cases very strong enhancement in the reaction rate was ...