Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium??Catalyzed Alkyne Cyclotrimerizations

…, CJ Tame, HC Hailes, TD Sheppard

Index: Foster, Robert W.; Tame, Christopher J.; Hailes, Helen C.; Sheppard, Tom D. Advanced Synthesis and Catalysis, 2013 , vol. 355, # 11-12 p. 2353 - 2360

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Citation Number: 11

Abstract

Abstract:(Cyclooctadiene)(pentamethylcyclopentadiene) ruthenium chloride [Cp* RuClACHTUNGTRENNUNG (cod)] has been used to catalyze the regioselective cyclization of amide-tethered diynes with monosubstituted alkynes to give polysubstituted isoindolinones. Notably, the presence of a trimethylsilyl group on the diyne generally led to complete control over the regioselectivity of the alkyne cyclotrimerization. The cyclization ...