One-pot synthesis of N-allylthioureas using supported reagents
T Aoyama, S Murata, Y Nagata, T Takido, M Kodomari
Index: Aoyama, Tadashi; Murata, Sumiko; Nagata, Yasutaka; Takido, Toshio; Kodomari, Mitsuo Tetrahedron Letters, 2005 , vol. 46, # 29 p. 4875 - 4878
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Citation Number: 18
Abstract
A simple and efficient method has been developed for the synthesis of N-allylthioureas from allylic bromides in one-pot by using a supported reagents system, KSCN/SiO2– RNH3OAc/Al2O3, in which allyl bromide reacts first with KSCN/SiO2 and the product, allyl isothiocyanate, reacts with RNH3OAc/Al2O3 to give the final product, N-allylthiourea, in good yield.
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