Synthesis and PAF antagonist activity of some 2, 5-diaryltetrahydrofurans incorporating PAF-like functional groups
S Smith, GJ Blackwell, DA Demaine, LG Garland…
Index: Smith; Blackwell; Demaine; Garland; Hodson; Hyde; Parke; Rose; Sawyer; Tilling European Journal of Medicinal Chemistry, 1996 , vol. 31, # 5 p. 347 - 358
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Abstract
This paper describes the synthesis and structure-activity relationships of a series of 2, 5- diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the known PAF antagonist L- 652,731 were replaced with functional groups present in PAF and in the 'PAF- like'antagonists. Activity was generally retained or enhanced when one aryl ring in L- ...
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