Fast DKR of Amines Using Isopropyl 2??Methoxyacetate as Acyl Donor
…, K Hult, ARA Palmans, EW Meijer
Index: Veld, Martijn A. J.; Hult, Karl; Palmans, Anja R. A.; Meijer European Journal of Organic Chemistry, 2007 , # 32 p. 5416 - 5421
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Citation Number: 24
Abstract
Abstract The dynamic kinetic resolution (DKR) of various primary amine substrates was performed using a modified version of the Bäckvall system. A single equivalent of isopropyl 2-methoxyacetate was used as acyl donor in combination with p-MeO Shvo complex as the racemization catalyst and Novozym 435 as the acylation catalyst. A reaction temperature of 100 C was employed to ensure a high racemization rate. Adding 2, 4-dimethyl-3-pentanol ...
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