Synthesis and cytotoxic activity of non-naturally substituted 4-oxycoumarin derivatives

…, G Delogu, S Vázquez-Rodríguez, L Santana…

Index: Serra, Silvia; Delogu, Giovanna; Casu, Laura; Vazquez-Rodriguez, Saleta; Santana, Lourdes; Uriarte, Eugenio; Chicca, Andrea; Gertsch, Juerg Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 18 p. 5791 - 5794,4

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Citation Number: 16

Abstract

Coumarins are a large family of natural and synthetic compounds exerting different pharmacological effects, including cytotoxic, anti-inflammatory or antimicrobial. In the present communication we report the synthesis of a series of 12 diversely substituted 4- oxycoumarin derivatives including methoxy substituted 4-hydroxycoumarins, methyl, methoxy or unsubstituted 3-aryl-4-hydroxycoumarins and 4-benzyloxycoumarins and their ...