Synthesis, biological evaluation and molecular modelling studies of novel ACD-and ABD-ring steroidomimetics as inhibitors of CYP17
MAEPB Mendieta, M Negri, C Jagusch, UE Hille…
Index: Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 1 p. 267 - 273
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Citation Number: 20
Abstract
... Bioorganic & Medicinal Chemistry Letters. ... a Pharmaceutical and Medicinal Chemistry, Saarland University, PO ... 1 Since it is in over 80% of the cases androgen dependent, the standard treatment is orchiectomy or its medicinal equivalent the chemical castration by gonadotropin ...
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