N-(arylalkyl) farnesylamines: new potent squalene synthetase inhibitors

…, FG Kathawala, T Scallen

Index: Prashad, Mahavir; Kathawala, F. G.; Scallen, T. Journal of Medicinal Chemistry, 1993 , vol. 36, # 10 p. 1501 - 1504

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Citation Number: 29

Abstract

Because of its strategic location in the cholesterol biosynthesis pathway, squalene synthetase enzyme is an attractive target for inhibition. Squalene synthetase catalyzes the transformation of farnesyl pyrophosphate (FPP) to squalene in two steps.'The fist step is the condensation of two molecules of FPP to presqualene pyrophosphate (PSPP), and the second step involves the reductive rearrangement of PSPP to squalene. Both steps have ...