7-Trifluoromethoxy and 7-Trifluoromethythio Derivatives of 1, 4-Benzodiazepines

F McEvoy, E Greenblatt, A Osterberg…

Index: McEvoy,F.J. et al. Journal of Medicinal Chemistry, 1968 , vol. 11, # 6 p. 1248 - 1250

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Citation Number: 15

Abstract

VIb, this reaction was superior in the 7-trifluoromethoxy series. These results with VI and VI11 suggest a reduced nucleophilicity for the nitrogen functions in the trifluoromethylthio series, an observation qualitatively in accord with the behavior predicted by the substituent constants for the ORF and SRF group~.~ In view of these synthetic difficulties other 1, 4- benzodiazepines were prepared only in the 7-trifluoromethoxy series.