Organic & biomolecular chemistry

Asymmetric hydrogenation of β-amino ketones with the bimetallic complex RuPHOX-Ru as the chiral catalyst

J Wang, D Liu, Y Liu, W Zhang

Index: Wang, Jiahao; Liu, Delong; Liu, Yangang; Zhang, Wanbin Organic and Biomolecular Chemistry, 2013 , vol. 11, # 23 p. 3855 - 3861

Full Text: HTML

Citation Number: 16

Abstract

Asymmetric hydrogenations of a series of β-amino ketones were carried out with a bimetallic complex (RuPHOX-Ru) as the chiral catalyst. Almost all the reactions (performed in a mixed solvent system of toluene and H2O in the presence of KOH) gave quantitative conversions into their respective products with up to 99.9% ee. The RuPHOX-Ru catalyst is stable to both moisture and air. The procedure has the benefits of being inexpensive, environmentally ...