Aminopyrazole Oligomers for β-SheetStabilization of Peptides

P Rzepecki, M Wehner, O Molt, R Zadmard…

Index: Rzepecki; Wehner; Molt; Zadmard; Harms; Schrader Synthesis, 2003 , # 12 p. 1815 - 1826

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Citation Number: 27

Abstract

Abstract A general concept for the stabilization of β-sheetsby designed artificial ligands is introduced. The ligands have twokey features: they contain acylated 3-aminopyrazoles with a DAD hydrogenbond donor and acceptor pattern, and they were synthesized as oligomersin order to multiply their hydrogen bond interactions with peptidesin the β-sheet conformation. Dimeric aminopyrazoles wereaccessible by reaction of the N1-Boc- ...