Ethyl 2, 2-bis (4-methylphenylsulfonamido) acetate to aromatic α-amino acids: stable substrates for catalytic arylation reactions
CS Marques, AJ Burke
Index: Marques, Carolina S.; Burke, Anthony J. Tetrahedron, 2013 , vol. 69, # 47 p. 10091 - 10097
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Citation Number: 9
Abstract
Abstract This paper reports the development of a novel methodology for the catalytic synthesis of aromatic α-amino acids, which involves the addition of aryl-organoboron reagents to α, α-ditosylamino esters derived from ethyl glyoxylate, using transition metal catalysts, like Rh and Pd. A library of α-amino esters (12 with Pd and 8 with Rh), was synthesized with moderate to excellent yields. A highest enantioselectivity of 30% ee was ...
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