Intramolecular CN bond addition of amides to alkynes using platinum catalyst
…, I Nakamura, Y Yamamoto
Index: Shimada, Tomohiro; Nakamura, Itaru; Yamamoto, Yoshinori Journal of the American Chemical Society, 2004 , vol. 126, # 34 p. 10546 - 10547
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Citation Number: 157
Abstract
The intramolecular aminoacylation of alkynes using ortho-alkynylacetanilides proceeds in very high yields in the presence of PtCl2 catalyst. This reaction provides not only a useful procedure for synthesizing 2, 3-disubstituted indoles at once from ortho-alkynylaniline derivatives, but also an interesting mechanistic aspect; the intramolecular CN bond addition of amides to alkynes takes place readily in the presence of Pt (II) catalyst.
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